The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 265077: Lupus La protein homolog

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 15 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
TRNA binding GO:0000049
Interacting selectively and non-covalently with transfer RNA.
2 P05455 (/IMP) P87058 (/IMP)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
2 P05455 (/IDA) P32067 (/IDA)
TRNA binding GO:0000049
Interacting selectively and non-covalently with transfer RNA.
1 P32067 (/ISO)
TRNA binding GO:0000049
Interacting selectively and non-covalently with transfer RNA.
1 P05455 (/TAS)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
1 P05455 (/IMP)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
1 P32067 (/ISO)
MRNA binding GO:0003729
Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.
1 P40796 (/ISS)
MRNA binding GO:0003729
Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.
1 P40796 (/NAS)
MRNA binding GO:0003729
Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.
1 P05455 (/TAS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
1 P05455 (/IPI)
5S rRNA primary transcript binding GO:0008098
Interacting selectively and non-covalently with the unprocessed 5S ribosomal RNA transcript.
1 P40796 (/IDA)
Poly(U) RNA binding GO:0008266
Interacting selectively and non-covalently with a sequence of uracil residues in an RNA molecule.
1 P05455 (/IMP)
Poly(U) RNA binding GO:0008266
Interacting selectively and non-covalently with a sequence of uracil residues in an RNA molecule.
1 P32067 (/ISO)
Sequence-specific mRNA binding GO:1990825
Interacting selectively and non-covalently with messenger RNA (mRNA) of a specific nucleotide composition or a specific sequence motif.
1 P05455 (/IMP)
Sequence-specific mRNA binding GO:1990825
Interacting selectively and non-covalently with messenger RNA (mRNA) of a specific nucleotide composition or a specific sequence motif.
1 P32067 (/ISO)

There are 21 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
TRNA processing GO:0008033
The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group.
3 P05455 (/IMP) P38656 (/IMP) P87058 (/IMP)
TRNA export from nucleus GO:0006409
The directed movement of tRNA from the nucleus to the cytoplasm.
2 P05455 (/IMP) P87058 (/IMP)
TRNA 5'-leader removal GO:0001682
Generation of the mature 5'-end of the tRNA, usually via an endonucleolytic cleavage by RNase P.
1 P05455 (/IGI)
TRNA 5'-leader removal GO:0001682
Generation of the mature 5'-end of the tRNA, usually via an endonucleolytic cleavage by RNase P.
1 P87058 (/IMP)
TRNA 5'-leader removal GO:0001682
Generation of the mature 5'-end of the tRNA, usually via an endonucleolytic cleavage by RNase P.
1 P32067 (/ISO)
Termination of RNA polymerase III transcription GO:0006386
The process in which transcription by RNA polymerase III is terminated; Pol III has an intrinsic ability to terminate transcription upon incorporation of 4 to 6 contiguous U residues.
1 P87058 (/TAS)
TRNA modification GO:0006400
The covalent alteration of one or more nucleotides within a tRNA molecule to produce a tRNA molecule with a sequence that differs from that coded genetically.
1 P05455 (/TAS)
TRNA export from nucleus GO:0006409
The directed movement of tRNA from the nucleus to the cytoplasm.
1 P32067 (/ISO)
TRNA processing GO:0008033
The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group.
1 P32067 (/ISO)
Histone mRNA metabolic process GO:0008334
The chemical reactions and pathways involving an mRNA encoding a histone.
1 P05455 (/TAS)
TRNA 3'-trailer cleavage, endonucleolytic GO:0034414
Endonucleolytic cleavage of the 3'-end of the pre-tRNA as part of the process of generating the mature 3'-end of the tRNA.
1 P87058 (/IMP)
TRNA 3'-trailer cleavage GO:0042779
Cleavage of the 3'-end of the pre-tRNA as part of the process of generating the mature 3'-end of the tRNA; may involve endonucleolytic or exonucleolytic cleavage, or both.
1 P87058 (/IGI)
TRNA 3'-end processing GO:0042780
The process in which the 3' end of a pre-tRNA molecule is converted to that of a mature tRNA.
1 P05455 (/IGI)
TRNA 3'-end processing GO:0042780
The process in which the 3' end of a pre-tRNA molecule is converted to that of a mature tRNA.
1 P87058 (/IMP)
TRNA 3'-end processing GO:0042780
The process in which the 3' end of a pre-tRNA molecule is converted to that of a mature tRNA.
1 P32067 (/ISO)
Nuclear histone mRNA catabolic process GO:0071045
The chemical reactions and pathways resulting in the breakdown of histone messenger RNA (mRNA) within the nucleus.
1 P05455 (/IMP)
Nuclear histone mRNA catabolic process GO:0071045
The chemical reactions and pathways resulting in the breakdown of histone messenger RNA (mRNA) within the nucleus.
1 P32067 (/ISO)
IRES-dependent viral translational initiation GO:0075522
Process by which viral mRNA translation is initiated, where a domain in the 5' untranslated region (UTR) of the viral mRNA called an internal ribosome entry site (IRES) binds the host 43S preinitiation complex, circumventing regular cap-dependent translation initiation.
1 P05455 (/IDA)
IRES-dependent viral translational initiation GO:0075522
Process by which viral mRNA translation is initiated, where a domain in the 5' untranslated region (UTR) of the viral mRNA called an internal ribosome entry site (IRES) binds the host 43S preinitiation complex, circumventing regular cap-dependent translation initiation.
1 P32067 (/ISO)
Protein localization to cytoplasmic stress granule GO:1903608
A process in which a protein is transported to, or maintained in, a location within a cytoplasmic stress granule.
1 P05455 (/IDA)
Protein localization to cytoplasmic stress granule GO:1903608
A process in which a protein is transported to, or maintained in, a location within a cytoplasmic stress granule.
1 P32067 (/ISO)

There are 9 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
4 P05455 (/IDA) P32067 (/IDA) P40796 (/IDA) P87058 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 P05455 (/IDA) P87058 (/IDA)
Nuclear chromosome, telomeric region GO:0000784
The terminal region of a linear nuclear chromosome that includes the telomeric DNA repeats and associated proteins.
1 P05455 (/IDA)
Nuclear chromosome, telomeric region GO:0000784
The terminal region of a linear nuclear chromosome that includes the telomeric DNA repeats and associated proteins.
1 P32067 (/ISO)
Euchromatin GO:0000791
A dispersed and relatively uncompacted form of chromatin.
1 P40796 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 P32067 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 P32067 (/ISO)
Intracellular ribonucleoprotein complex GO:0030529
An intracellular macromolecular complex containing both protein and RNA molecules.
1 P05455 (/TAS)
Phagocytic vesicle GO:0045335
A membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis.
1 Q54TG6 (/IDA)