The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 262686: Rap guanine nucleotide exchange factor 3

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 10 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
2 O95398 (/IPI) Q8VCC8 (/IPI)
Guanyl-nucleotide exchange factor activity GO:0005085
Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
1 O95398 (/EXP)
Guanyl-nucleotide exchange factor activity GO:0005085
Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
1 Q8VCC8 (/IDA)
Guanyl-nucleotide exchange factor activity GO:0005085
Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
1 Q8VCC8 (/ISO)
Guanyl-nucleotide exchange factor activity GO:0005085
Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
1 O95398 (/TAS)
Rap guanyl-nucleotide exchange factor activity GO:0017034
Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rap family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
1 O95398 (/IMP)
Rap guanyl-nucleotide exchange factor activity GO:0017034
Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rap family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
1 Q8VCC8 (/ISO)
Rap guanyl-nucleotide exchange factor activity GO:0017034
Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rap family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
1 Q8VCC8 (/ISS)
Protein domain specific binding GO:0019904
Interacting selectively and non-covalently with a specific domain of a protein.
1 O95398 (/IPI)
Protein domain specific binding GO:0019904
Interacting selectively and non-covalently with a specific domain of a protein.
1 Q8VCC8 (/ISO)

There are 36 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Signal transduction GO:0007165
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
1 O95398 (/TAS)
Cell proliferation GO:0008283
The multiplication or reproduction of cells, resulting in the expansion of a cell population.
1 O95398 (/TAS)
CAMP-mediated signaling GO:0019933
Any intracellular signal transduction in which the signal is passed on within the cell via cyclic AMP (cAMP). Includes production of cAMP, and downstream effectors that further transmit the signal within the cell.
1 O95398 (/NAS)
Positive regulation of cAMP catabolic process GO:0030822
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate).
1 O95398 (/NAS)
Rap protein signal transduction GO:0032486
A series of molecular signals within the cell that are mediated by a member of the Rap family of proteins switching to a GTP-bound active state.
1 O95398 (/IMP)
Rap protein signal transduction GO:0032486
A series of molecular signals within the cell that are mediated by a member of the Rap family of proteins switching to a GTP-bound active state.
1 Q8VCC8 (/ISO)
Rap protein signal transduction GO:0032486
A series of molecular signals within the cell that are mediated by a member of the Rap family of proteins switching to a GTP-bound active state.
1 Q8VCC8 (/ISS)
Positive regulation of peptidyl-serine phosphorylation GO:0033138
Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-serine.
1 O95398 (/IDA)
Positive regulation of peptidyl-serine phosphorylation GO:0033138
Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-serine.
1 Q8VCC8 (/ISO)
Negative regulation of syncytium formation by plasma membrane fusion GO:0034242
Any process that decreases the frequency, rate or extent of the formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells.
1 O95398 (/IMP)
Negative regulation of syncytium formation by plasma membrane fusion GO:0034242
Any process that decreases the frequency, rate or extent of the formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells.
1 Q8VCC8 (/ISO)
Positive regulation of GTPase activity GO:0043547
Any process that activates or increases the activity of a GTPase.
1 O95398 (/IMP)
Positive regulation of GTPase activity GO:0043547
Any process that activates or increases the activity of a GTPase.
1 Q8VCC8 (/ISO)
Positive regulation of GTPase activity GO:0043547
Any process that activates or increases the activity of a GTPase.
1 Q8VCC8 (/ISS)
Positive regulation of angiogenesis GO:0045766
Any process that activates or increases angiogenesis.
1 O95398 (/IMP)
Positive regulation of angiogenesis GO:0045766
Any process that activates or increases angiogenesis.
1 Q8VCC8 (/ISO)
Positive regulation of angiogenesis GO:0045766
Any process that activates or increases angiogenesis.
1 Q8VCC8 (/ISS)
Positive regulation of protein export from nucleus GO:0046827
Any process that activates or increases the frequency, rate or extent of directed movement of proteins from the nucleus into the cytoplasm.
1 O95398 (/IDA)
Positive regulation of protein export from nucleus GO:0046827
Any process that activates or increases the frequency, rate or extent of directed movement of proteins from the nucleus into the cytoplasm.
1 Q8VCC8 (/ISO)
Regulation of insulin secretion GO:0050796
Any process that modulates the frequency, rate or extent of the regulated release of insulin.
1 O95398 (/TAS)
Positive regulation of stress fiber assembly GO:0051496
Any process that activates or increases the frequency, rate or extent of the assembly of a stress fiber, a bundle of microfilaments and other proteins found in fibroblasts.
1 O95398 (/IMP)
Positive regulation of stress fiber assembly GO:0051496
Any process that activates or increases the frequency, rate or extent of the assembly of a stress fiber, a bundle of microfilaments and other proteins found in fibroblasts.
1 Q8VCC8 (/ISO)
Positive regulation of stress fiber assembly GO:0051496
Any process that activates or increases the frequency, rate or extent of the assembly of a stress fiber, a bundle of microfilaments and other proteins found in fibroblasts.
1 Q8VCC8 (/ISS)
Positive regulation of syncytium formation by plasma membrane fusion GO:0060143
Any process that increases the frequency, rate or extent of the formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells.
1 O95398 (/IMP)
Positive regulation of syncytium formation by plasma membrane fusion GO:0060143
Any process that increases the frequency, rate or extent of the formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells.
1 Q8VCC8 (/ISO)
Establishment of endothelial barrier GO:0061028
The establishment of a barrier between endothelial cell layers, such as those in the brain, lung or intestine, to exert specific and selective control over the passage of water and solutes, thus allowing formation and maintenance of compartments that differ in fluid and solute composition.
1 O95398 (/IMP)
Establishment of endothelial barrier GO:0061028
The establishment of a barrier between endothelial cell layers, such as those in the brain, lung or intestine, to exert specific and selective control over the passage of water and solutes, thus allowing formation and maintenance of compartments that differ in fluid and solute composition.
1 Q8VCC8 (/ISO)
Establishment of endothelial barrier GO:0061028
The establishment of a barrier between endothelial cell layers, such as those in the brain, lung or intestine, to exert specific and selective control over the passage of water and solutes, thus allowing formation and maintenance of compartments that differ in fluid and solute composition.
1 Q8VCC8 (/ISS)
Cellular response to cAMP GO:0071320
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) stimulus.
1 O95398 (/IDA)
Cellular response to cAMP GO:0071320
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) stimulus.
1 Q8VCC8 (/ISO)
Cellular response to cAMP GO:0071320
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) stimulus.
1 Q8VCC8 (/ISS)
Positive regulation of protein acetylation GO:1901985
Any process that activates or increases the frequency, rate or extent of protein acetylation.
1 O95398 (/IMP)
Positive regulation of protein acetylation GO:1901985
Any process that activates or increases the frequency, rate or extent of protein acetylation.
1 Q8VCC8 (/ISO)
Regulation of actin cytoskeleton reorganization GO:2000249
Any process that modulates the frequency, rate or extent of actin cytoskeleton reorganization.
1 O95398 (/IMP)
Regulation of actin cytoskeleton reorganization GO:2000249
Any process that modulates the frequency, rate or extent of actin cytoskeleton reorganization.
1 Q8VCC8 (/ISO)
Regulation of actin cytoskeleton reorganization GO:2000249
Any process that modulates the frequency, rate or extent of actin cytoskeleton reorganization.
1 Q8VCC8 (/ISS)

There are 10 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 O95398 (/TAS)
Microvillus GO:0005902
Thin cylindrical membrane-covered projections on the surface of an animal cell containing a core bundle of actin filaments. Present in especially large numbers on the absorptive surface of intestinal cells.
1 O95398 (/IDA)
Microvillus GO:0005902
Thin cylindrical membrane-covered projections on the surface of an animal cell containing a core bundle of actin filaments. Present in especially large numbers on the absorptive surface of intestinal cells.
1 Q8VCC8 (/ISO)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 O95398 (/TAS)
Lamellipodium GO:0030027
A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments.
1 O95398 (/IDA)
Lamellipodium GO:0030027
A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments.
1 Q8VCC8 (/ISO)
Filopodium GO:0030175
Thin, stiff, actin-based protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal or dendritic growth cone, or a dendritic shaft.
1 O95398 (/IDA)
Filopodium GO:0030175
Thin, stiff, actin-based protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal or dendritic growth cone, or a dendritic shaft.
1 Q8VCC8 (/ISO)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
1 O95398 (/IDA)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
1 Q8VCC8 (/ISO)