CATH Classification

Domain Context

CATH Clusters

Superfamily Transcription Factor, Ets-1
Functional Family Tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase variant

Enzyme Information

2.4.2.30
NAD(+) ADP-ribosyltransferase.
based on mapping to UniProt O95271
NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D- ribosyl)(n+1)-acceptor.
-!- The ADP-D-ribosyl group of NAD(+) is transferred to an acceptor carboxy group on a histone or the enzyme itself, and further ADP- ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units.

UniProtKB Entries (1)

O95271
TNKS1_HUMAN
Homo sapiens
Tankyrase-1

PDB Structure

PDB 5JTI
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Tankyrase Requires SAM Domain-Dependent Polymerization to Support Wnt-beta-Catenin Signaling.
Mariotti, L., Templeton, C.M., Ranes, M., Paracuellos, P., Cronin, N., Beuron, F., Morris, E., Guettler, S.
Mol.Cell