CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.720 | NAD(P)-binding Rossmann-like Domain |
Domain Context
CATH Clusters
| Superfamily | NAD(P)-binding Rossmann-like Domain |
| Functional Family | Photoreceptor dehydrogenase, isoform C |
Enzyme Information
| 1.1.1.105 |
All-trans-retinol dehydrogenase (NAD(+)).
based on mapping to UniProt Q9VV42
All-trans-retinol-[cellular-retinol-binding-protein] + NAD(+) = all- trans-retinal-[cellular-retinol-binding-protein] + NADH.
-!- The enzyme recognizes all-trans-retinol and all-trans-retinal as substrates and exhibits a strong preference for NAD(+)/NADH as cofactors. -!- Recognizes the substrate both in free form and when bound to cellular-retinol-binding-protein (CRBP1), but has higher affinity for the bound form. -!- No activity with 11-cis-retinol or 11-cis-retinal (cf. EC 1.1.1.315). -!- Also active with 3-alpha-hydroxysteroids.
|
| 1.1.1.1 |
Alcohol dehydrogenase.
based on mapping to UniProt Q9VV42
(1) An alcohol + NAD(+) = an aldehyde or ketone + NADH. (2) A secondary alcohol + NAD(+) = a ketone + NADH.
-!- Acts on primary or secondary alcohols or hemi-acetals with very broad specificity; however the enzyme oxidizes methanol much more poorly than ethanol. -!- The animal, but not the yeast, enzyme acts also on cyclic secondary alcohols.
|
UniProtKB Entries (1)
| Q9VV42 |
Q9VV42_DROME
Drosophila melanogaster
HL08057p
|
PDB Structure
| PDB | 5ILG |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structural Insights into the Drosophila melanogaster Retinol Dehydrogenase, a Member of the Short-Chain Dehydrogenase/Reductase Family.
Biochemistry
|