CATH Classification

Domain Context

CATH Clusters

Superfamily SET domain
Functional Family Probable histone-lysine N-methyltransferase set-2

Enzyme Information

2.1.1.43
Histone-lysine N-methyltransferase.
based on mapping to UniProt Q03164
S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].

UniProtKB Entries (1)

Q9UBL3
ASH2L_HUMAN
Homo sapiens
Set1/Ash2 histone methyltransferase complex subunit ASH2

PDB Structure

PDB 5F6L
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural basis for activity regulation of MLL family methyltransferases.
Li, Y., Han, J., Zhang, Y., Cao, F., Liu, Z., Li, S., Wu, J., Hu, C., Wang, Y., Shuai, J., Chen, J., Cao, L., Li, D., Shi, P., Tian, C., Zhang, J., Dou, Y., Li, G., Chen, Y., Lei, M.
Nature