CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.720 | NAD(P)-binding Rossmann-like Domain |
Domain Context
CATH Clusters
| Superfamily | NAD(P)-binding Rossmann-like Domain |
| Functional Family | Putative progesterone 5-beta-reductase |
Enzyme Information
| 1.3.1.99 |
Iridoid synthase.
based on mapping to UniProt K7WDL7
(6E)-8-oxogeranial + NAD(P)H = cis-trans-nepetalactol + NAD(P)(+).
-!- Isolated from the plant Catharanthus roseus. -!- The reaction may involve cyclization via a Diels-Alder or Michael reaction. -!- Iridoids are involved in the biosynthesis of many indole alkaloids. -!- The cyclic hemiacetal is readily hydrolyzed to the corresponding dial.
|
UniProtKB Entries (1)
| K7WDL7 |
IRIS_CATRO
Catharanthus roseus
Iridoid synthase
|
PDB Structure
| PDB | 5COA |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structure of iridoid synthase in complex with NADP(+)/8-oxogeranial reveals the structural basis of its substrate specificity.
J.Struct.Biol.
|