CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.10 | Orthogonal Bundle |
|
1.10.630 | Cytochrome p450 |
|
1.10.630.10 | Cytochrome P450 |
Domain Context
CATH Clusters
| Superfamily | Cytochrome P450 |
| Functional Family | Steroid 21-hydroxylase, CYP21 |
Enzyme Information
| 1.14.14.16 |
Steroid 21-monooxygenase.
based on mapping to UniProt P08686
A C(21) steroid + [reduced NADPH--hemoprotein reductase] + O(2) = a 21-hydroxy-C(21)-steroid + [oxidized NADPH--hemoprotein reductase] + H(2)O.
-!- For the conversion of progesterone and 17-alpha-hydroxyprogesterone to their respective 21-hydroxylated derivatives, 11-deoxycorticosterone and 11-deoxycortisol. -!- Involved in the biosynthesis of the hormones aldosterone and cortisol. -!- The electron donor is EC 1.6.2.4. -!- Formerly EC 1.14.1.8, EC 1.14.99.10 and EC 1.99.1.11.
|
UniProtKB Entries (1)
| P08686 |
CP21A_HUMAN
Homo sapiens
Steroid 21-hydroxylase
|
PDB Structure
| PDB | 4Y8W |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Human Cytochrome P450 21A2, the Major Steroid 21-Hydroxylase: STRUCTURE OF THE ENZYMEPROGESTERONE SUBSTRATE COMPLEX AND RATE-LIMITING C-H BOND CLEAVAGE.
J.Biol.Chem.
|