CATH Domain 4xwgA01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.1820	Alpha/Beta hydrolase fold, catalytic domain

Domain Context

CATH Clusters

Superfamily	3.40.50.1820
Functional Family	Group XV phospholipase A2

Enzyme Information

2.3.1.43

Phosphatidylcholine--sterol O-acyltransferase.

based on mapping to UniProt P04180

Phosphatidylcholine + a sterol = 1-acylglycerophosphocholine + a sterol ester.

-!- Palmitoyl, oleoyl, and linoleoyl can be transferred; a number of sterols, including cholesterol, can act as acceptors. -!- The bacterial enzyme also catalyzes the reactions of EC 3.1.1.4 and EC 3.1.1.5.

UniProtKB Entries (1)

P04180

LCAT_HUMAN

Homo sapiens

Phosphatidylcholine-sterol acyltransferase

PDB Structure

PDB	4XWG
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	The high-resolution crystal structure of human LCAT. Piper, D.E., Romanow, W.G., Gunawardane, R.N., Fordstrom, P., Masterman, S., Pan, O., Thibault, S.T., Zhang, R., Meininger, D., Schwarz, M., Wang, Z., King, C., Zhou, M., Walker, N.P. J.Lipid Res.