CATH Classification

Domain Context

CATH Clusters

Superfamily 3.40.50.1820
Functional Family Group XV phospholipase A2

Enzyme Information

2.3.1.43
Phosphatidylcholine--sterol O-acyltransferase.
based on mapping to UniProt P04180
Phosphatidylcholine + a sterol = 1-acylglycerophosphocholine + a sterol ester.
-!- Palmitoyl, oleoyl, and linoleoyl can be transferred; a number of sterols, including cholesterol, can act as acceptors. -!- The bacterial enzyme also catalyzes the reactions of EC 3.1.1.4 and EC 3.1.1.5.

UniProtKB Entries (1)

P04180
LCAT_HUMAN
Homo sapiens
Phosphatidylcholine-sterol acyltransferase

PDB Structure

PDB 4XWG
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The high-resolution crystal structure of human LCAT.
Piper, D.E., Romanow, W.G., Gunawardane, R.N., Fordstrom, P., Masterman, S., Pan, O., Thibault, S.T., Zhang, R., Meininger, D., Schwarz, M., Wang, Z., King, C., Zhou, M., Walker, N.P.
J.Lipid Res.