CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.90 | Alpha-Beta Complex |
|
3.90.79 | Nucleoside Triphosphate Pyrophosphohydrolase |
|
3.90.79.10 | Nucleoside Triphosphate Pyrophosphohydrolase |
Domain Context
CATH Clusters
| Superfamily | Nucleoside Triphosphate Pyrophosphohydrolase |
| Functional Family | MutT protein [7,8-dihydro-8-oxoguanine-triphosphatase] |
Enzyme Information
| 3.6.1.55 |
8-oxo-dGTP diphosphatase.
based on mapping to UniProt Q9KPH6
8-oxo-dGTP + H(2)O = 8-oxo-dGMP + diphosphate.
-!- This enzyme hydrolyzes the phosphoanhydride bond between the alpha and beta phosphate of 8-oxoguanine-containing nucleoside di- and triphosphates thereby preventing misincorporation of the oxidized purine nucleoside triphosphates into DNA. -!- It does not hydrolyze 2-hydroxy-dATP (cf. EC 3.6.1.56).
|
| 3.6.1.- |
In phosphorus-containing anhydrides.
based on mapping to UniProt Q9KPH6
|
UniProtKB Entries (1)
| Q9KPH6 |
Q9KPH6_VIBCH
Vibrio cholerae O1 biovar El Tor str. N16961
Mutator MutT protein
|
PDB Structure
| PDB | 4V14 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Mutt from the Fish Pathogen Aliivibrio Salmonicida is a Cold-Active Nucleotide-Pool Sanitization Enzyme with Unexpectedly High Thermostability.
FEBS Open Bio
|