CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.150 | Vaccinia Virus protein VP39 |
Domain Context
CATH Clusters
| Superfamily | Vaccinia Virus protein VP39 |
| Functional Family | Probable 18S rRNA (guanine-N(7))-methyltransferase |
Enzyme Information
| 2.1.1.309 |
18S rRNA (guanine(1575)-N(7))-methyltransferase.
based on mapping to UniProt P25627
S-adenosyl-L-methionine + guanine(1575) in 18S rRNA = S-adenosyl-L- homocysteine + N(7)-methylguanine(1575) in 18S rRNA.
-!- The enzyme, found in eukaryotes, is involved in pre-rRNA processing. -!- The numbering corresponds to the enzyme from the yeast Saccharomyces cerevisiae.
|
UniProtKB Entries (1)
| P53738 |
TR112_YEAST
Saccharomyces cerevisiae S288C
Multifunctional methyltransferase subunit TRM112
|
PDB Structure
| PDB | 4QTT |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structural and functional studies of Bud23-Trm112 reveal 18S rRNA N7-G1575 methylation occurs on late 40S precursor ribosomes
Proc.Natl.Acad.Sci.USA
|