CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.1820 | Alpha/Beta hydrolase fold, catalytic domain |
Domain Context
CATH Clusters
| Superfamily | 3.40.50.1820 |
| Functional Family | Juvenile hormone epoxide hydrolase |
Enzyme Information
| 3.3.2.9 |
Microsomal epoxide hydrolase.
based on mapping to UniProt Q6U6J0
Cis-stilbene oxide + H(2)O = (+)-(1R,2R)-1,2-diphenylethane-1,2-diol.
-!- Involved in the metabolism of numerous xenobiotics, such as 1,3- butadiene oxide, styrene oxide and the polycyclic aromatic hydrocarbon benzo[a]pyrene 4,5-oxide. -!- In a series of oxiranes with a lipophilic substituent of sufficient size (styrene oxides), monosubstituted as well as 1,1- and cis-1,2- disubstituted oxiranes serve as substrates or inhibitors of the enzyme, while trans-1,2-disubstituted, tri- and tetra-substituted oxiranes are not substrates. -!- The reaction involves the formation of an hydroxyalkyl-enzyme intermediate. -!- Formerly EC 3.3.2.3, EC 4.2.1.63 and EC 4.2.1.64.
|
UniProtKB Entries (1)
| Q6U6J0 |
HYEP_BOMMO
Bombyx mori
Juvenile hormone epoxide hydrolase
|
PDB Structure
| PDB | 4QLA |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Crystal structure of juvenile hormone epoxide hydrolase from the silkworm Bombyx mori
Proteins
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