CATH Classification

Domain Context

CATH Clusters

Superfamily DNA-directed RNA polymerase, subunit 2, domain 6
Functional Family DNA-directed RNA polymerase subunit B

Enzyme Information

2.7.7.6
DNA-directed RNA polymerase.
based on mapping to UniProt Q5JE32
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. -!- Can initiate a chain de novo. -!- In eukaryotes three forms of the enzyme have been distinguished on the basis of sensitivity of alpha-amanitin, and the type of RNA synthesized. -!- See also EC 2.7.7.19 and EC 2.7.7.48.

UniProtKB Entries (1)

Q5JJD0
RPOK_THEKO
Thermococcus kodakarensis KOD1
DNA-directed RNA polymerase subunit K

PDB Structure

PDB 4QIW
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The X-ray crystal structure of the euryarchaeal RNA polymerase in an open-clamp configuration.
Jun, S.H., Hirata, A., Kanai, T., Santangelo, T.J., Imanaka, T., Murakami, K.S.
Nat Commun