CATH Classification
Level | CATH Code | Description |
---|---|---|
2 | Mainly Beta | |
2.60 | Sandwich | |
2.60.120 | Jelly Rolls | |
2.60.120.10 | Jelly Rolls |
Domain Context
CATH Clusters
Superfamily | Jelly Rolls |
Functional Family | cGMP-dependent protein kinase, putative |
Enzyme Information
2.7.11.12 |
cGMP-dependent protein kinase.
based on mapping to UniProt Q8I719
ATP + a protein = ADP + a phosphoprotein.
-!- cGMP is required to activate this enzyme. -!- The enzyme occurs as a dimer in higher eukaryotes. -!- The C-terminal region of each polypeptide chain contains the catalytic domain that includes the ATP and protein substrate binding sites. -!- This domain catalyzes the phosphorylation by ATP to specific serine or threonine residues in protein substrates. -!- The enzyme also has two allosteric cGMP-binding sites (sites A and B). -!- Binding of cGMP causes a conformational change that is associated with activation of the kinase. -!- Formerly EC 2.7.1.37.
|
UniProtKB Entries (1)
Q8I719 |
Q8I719_PLAF7
Plasmodium falciparum 3D7
CGMP-dependent protein kinase
|
PDB Structure
PDB | 4OFG |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Crystal Structures of the Carboxyl cGMP Binding Domain of the Plasmodium falciparum cGMP-dependent Protein Kinase Reveal a Novel Capping Triad Crucial for Merozoite Egress.
Plos Pathog.
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