CATH Classification
Level | CATH Code | Description |
---|---|---|
3 | Alpha Beta | |
3.30 | 2-Layer Sandwich | |
3.30.40 | Herpes Virus-1 | |
3.30.40.10 | Zinc/RING finger domain, C3HC4 (zinc finger) |
Domain Context
CATH Clusters
Superfamily | Zinc/RING finger domain, C3HC4 (zinc finger) |
Functional Family | Lysine-specific demethylase 2B isoform 1 |
Enzyme Information
1.14.11.27 |
[Histone H3]-lysine-36 demethylase.
based on mapping to UniProt Q8NHM5
(1) Protein N(6),N(6)-dimethyl-L-lysine + 2-oxoglutarate + O(2) = protein N(6)-methyl-L-lysine + succinate + formaldehyde + CO(2). (2) Protein N(6)-methyl-L-lysine + 2-oxoglutarate + O(2) = protein L-lysine + succinate + formaldehyde + CO(2).
-!- Of the seven potential methylation sites in histones H3 (K4, K9, K27, K36, K79) and H4 (K20, R3) from HeLa cells, the enzyme is specific for Lys-36. -!- Lysine residues exist in three methylation states (mono-, di- and trimethylated). -!- The enzyme preferentially demethylates the dimethyl form of Lys-36 (K36me2), which is its natural substrate, to form the monomethyl and unmethylated forms of Lys-36. -!- It can also demethylate the monomethyl- but not the trimethyl form of Lys-36.
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UniProtKB Entries (1)
Q8NHM5 |
KDM2B_HUMAN
Homo sapiens
Lysine-specific demethylase 2B
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PDB Structure
PDB | 4O64 |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
DNA Sequence Recognition of Human CXXC Domains and Their Structural Determinants.
Structure
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