CATH Classification

Domain Context

CATH Clusters

Superfamily Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain
Functional Family Zinc uptake transcriptional repressor

Enzyme Information

2.7.7.6
DNA-directed RNA polymerase.
based on mapping to UniProt P0AC51
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. -!- Can initiate a chain de novo. -!- In eukaryotes three forms of the enzyme have been distinguished on the basis of sensitivity of alpha-amanitin, and the type of RNA synthesized. -!- See also EC 2.7.7.19 and EC 2.7.7.48.

UniProtKB Entries (1)

P0AC51
ZUR_ECOLI
Escherichia coli K-12
Zinc uptake regulation protein

PDB Structure

PDB 4MTD
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural and Mechanistic Basis of Zinc Regulation Across the E. coli Zur Regulon.
Gilston, B.A., Wang, S., Marcus, M.D., Canalizo-Hernandez, M.A., Swindell, E.P., Xue, Y., Mondragon, A., O'Halloran, T.V.
Plos Biol.