CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.30 | 2-Layer Sandwich |
|
3.30.1700 | lpxc deacetylase, domain 1 |
|
3.30.1700.10 | lpxc deacetylase, domain 2 |
Domain Context
CATH Clusters
| Superfamily | lpxc deacetylase, domain 2 |
| Functional Family | UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase, putative |
Enzyme Information
| 3.5.1.108 |
UDP-3-O-acyl-N-acetylglucosamine deacetylase.
based on mapping to UniProt P0A725
UDP-3-O-((3R)-3-hydroxytetradecanoyl)-N-acetyl-alpha-D-glucosamine + H(2)O = UDP-3-O-((3R)-3-hydroxytetradecanoyl)-alpha-D-glucosamine + acetate.
-!- The enzyme catalyzes a committed step in the biosynthesis of lipid A. -!- Formerly EC 3.5.1.n1.
|
| 3.5.1.- |
In linear amides.
based on mapping to UniProt P0A725
|
UniProtKB Entries (1)
| P0A725 |
LPXC_ECOLI
Escherichia coli K-12
UDP-3-O-acyl-N-acetylglucosamine deacetylase
|
PDB Structure
| PDB | 4MQY |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structural Basis of the Promiscuous Inhibitor Susceptibility of Escherichia coli LpxC.
Acs Chem.Biol.
|
