CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
2 | Mainly Beta |
|
2.170 | Beta Complex |
|
2.170.270 | Beta-clip-like |
|
2.170.270.10 | SET domain |
Domain Context
CATH Clusters
| Superfamily | SET domain |
| Functional Family | PREDICTED: histone-lysine N-methyltransferase EZH1-like |
Enzyme Information
| 2.1.1.43 |
Histone-lysine N-methyltransferase.
based on mapping to UniProt Q15910
S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].
|
UniProtKB Entries (1)
| Q15910 |
EZH2_HUMAN
Homo sapiens
Histone-lysine N-methyltransferase EZH2
|
PDB Structure
| PDB | 4MI0 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structure of the catalytic domain of EZH2 reveals conformational plasticity in cofactor and substrate binding sites and explains oncogenic mutations.
Plos One
|