CATH Classification

Domain Context

CATH Clusters

Superfamily Oligo-1,6-glucosidase; Domain 2
Functional Family Trehalose synthase (Maltose alpha-D-glucosyltransferase)

Enzyme Information

3.2.1.1
Alpha-amylase.
based on mapping to UniProt I6X8K8
Endohydrolysis of (1->4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1->4)-alpha-linked D-glucose units.
-!- Acts on starch, glycogen and related polysaccharides and oligosaccharides in a random manner; reducing groups are liberated in the alpha-configuration. -!- The term 'alpha' relates to the initial anomeric configuration of the free sugar group released and not to the configuration of the linkage hydrolyzed.
5.4.99.-
Transferring other groups.
based on mapping to UniProt I6X8K8
5.4.99.16
Maltose alpha-D-glucosyltransferase.
based on mapping to UniProt I6X8K8
Maltose = alpha,alpha-trehalose.

UniProtKB Entries (1)

I6X8K8
I6X8K8_MYCTU
Mycobacterium tuberculosis H37Rv
Trehalose synthase

PDB Structure

PDB 4LXF
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Synthesis of alpha-glucan in mycobacteria involves a hetero-octameric complex of trehalose synthase TreS and Maltokinase Pep2.
Roy, R., Usha, V., Kermani, A., Scott, D.J., Hyde, E.I., Besra, G.S., Alderwick, L.J., Futterer, K.
Acs Chem.Biol.