CATH Classification
Level | CATH Code | Description |
---|---|---|
2 | Mainly Beta | |
2.130 | 7 Propeller | |
2.130.10 | Methylamine Dehydrogenase; Chain H | |
2.130.10.10 | YVTN repeat-like/Quinoprotein amine dehydrogenase |
Domain Context
CATH Clusters
Superfamily | YVTN repeat-like/Quinoprotein amine dehydrogenase |
Functional Family | Pre-mRNA-processing factor 19 |
Enzyme Information
2.3.2.27 |
RING-type E3 ubiquitin transferase.
based on mapping to UniProt Q9UMS4
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)- ubiquitinyl-[acceptor protein]-L-lysine.
-!- The RING domain of E3 ubiquitin transferase serves as a mediator bringing the ubiquitin-charged E2 ubiquitin-conjugating enzyme and the acceptor protein together to enable the direct transfer of ubiquitin through the formation of an isopeptide bond between the C-terminal glycine residue of ubiquitin an the epsilon-amino group of an L-lysine residue of the acceptor protein. -!- The RING-E3 domain does not form a catalytic thioester intermediate with ubiquitin (unlike the HECT domain, EC 2.3.2.26). -!- RING-type ubiquitin transferases may occur as single-chain enzymes but also in dimeric forms or in multi-subunit assemblies. -!- Formerly EC 6.3.2.19 and EC 6.3.2.21.
|
UniProtKB Entries (1)
Q9UMS4 |
PRP19_HUMAN
Homo sapiens
Pre-mRNA-processing factor 19
|
PDB Structure
PDB | 4LG8 |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Crystal structure of the WD40 domain of human PRPF19.
Biochem. Biophys. Res. Commun.
|