CATH Classification

Domain Context

CATH Clusters

Superfamily YVTN repeat-like/Quinoprotein amine dehydrogenase
Functional Family Pre-mRNA-processing factor 19

Enzyme Information
RING-type E3 ubiquitin transferase.
based on mapping to UniProt Q9UMS4
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)- ubiquitinyl-[acceptor protein]-L-lysine.
-!- The RING domain of E3 ubiquitin transferase serves as a mediator bringing the ubiquitin-charged E2 ubiquitin-conjugating enzyme and the acceptor protein together to enable the direct transfer of ubiquitin through the formation of an isopeptide bond between the C-terminal glycine residue of ubiquitin an the epsilon-amino group of an L-lysine residue of the acceptor protein. -!- The RING-E3 domain does not form a catalytic thioester intermediate with ubiquitin (unlike the HECT domain, EC -!- RING-type ubiquitin transferases may occur as single-chain enzymes but also in dimeric forms or in multi-subunit assemblies. -!- Formerly EC and EC

UniProtKB Entries (1)

Homo sapiens
Pre-mRNA-processing factor 19

PDB Structure

External Links
Primary Citation
Crystal structure of the WD40 domain of human PRPF19.
Zhang, Y., Li, Y., Liang, X., Zhu, Z., Sun, H., He, H., Min, J., Liao, S., Liu, Y.
Biochem. Biophys. Res. Commun.