CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.720 | NAD(P)-binding Rossmann-like Domain |
Domain Context
CATH Clusters
| Superfamily | NAD(P)-binding Rossmann-like Domain |
| Functional Family | Quinone oxidoreductase-like protein At1g23740, chloroplastic |
Enzyme Information
| 1.3.1.105 |
2-methylene-furan-3-one reductase.
based on mapping to UniProt O23939
4-hydroxy-2,5-dimethylfuran-3(2H)-one + NAD(P)(+) = 4-hydroxy-5-methyl-2- methylenefuran-3(2H)-one + NAD(P)H.
-!- In the fruit-ripening process of strawberry (Fragaria x ananassa) the reaction is catalyzed in the reverse direction from that shown. -!- 4-hydroxy-2,5-dimethylfuran-3(2H)-one is one of the major aroma compounds in the fruits. -!- The enzyme has also been detected in tomato (Solanum lycopersicum) fruits. -!- NADPH is the preferred cofactor.
|
UniProtKB Entries (1)
| O23939 |
ENOX_FRAVE
Fragaria vesca
2-methylene-furan-3-one reductase
|
PDB Structure
| PDB | 4IDA |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structural basis for the enzymatic formation of the key strawberry flavor compound 4-hydroxy-2,5-dimethyl-3(2H)-furanone
J.Biol.Chem.
|