CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.30 | 2-Layer Sandwich |
|
3.30.230 | Ribosomal Protein S5; domain 2 |
|
3.30.230.10 |
Domain Context
CATH Clusters
| Superfamily | 3.30.230.10 |
| Functional Family | DNA gyrase subunit B |
Enzyme Information
| 5.99.1.3 |
DNA topoisomerase (ATP-hydrolyzing).
based on mapping to UniProt D6ZLV0
ATP-dependent breakage, passage and rejoining of double-stranded DNA.
-!- Can introduce negative superhelical turns into double-stranded circular DNA. -!- One unit has nicking-closing activity, and another catalyzes super- twisting and hydrolysis of ATP (cf. EC 5.99.1.2).
|
| 5.99.1.3 |
DNA topoisomerase (ATP-hydrolyzing).
based on mapping to UniProt Q3HZ71
ATP-dependent breakage, passage and rejoining of double-stranded DNA.
-!- Can introduce negative superhelical turns into double-stranded circular DNA. -!- One unit has nicking-closing activity, and another catalyzes super- twisting and hydrolysis of ATP (cf. EC 5.99.1.2).
|
UniProtKB Entries (2)
| D6ZLV0 |
D6ZLV0_STRP0
Streptococcus pneumoniae TCH8431/19A
DNA topoisomerase 4 subunit A
|
| Q3HZ71 |
Q3HZ71_STREE
Streptococcus pneumoniae
DNA topoisomerase 4 subunit B
|
PDB Structure
| PDB | 4I3H |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structure of an 'open' clamp type II topoisomerase-DNA complex provides a mechanism for DNA capture and transport.
Nucleic Acids Res.
|
