CATH Classification

Domain Context

CATH Clusters

Superfamily Plasminogen Kringle 4
Functional Family Tyrosine-protein kinase transmembrane receptor

Enzyme Information

3.4.21.5
Thrombin.
based on mapping to UniProt P00734
Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B.
-!- More selective than trypsin and plasmin. -!- Belongs to peptidase family S1. -!- Formerly EC 3.4.4.13.

UniProtKB Entries (1)

P00734
THRB_HUMAN
Homo sapiens
Prothrombin

PDB Structure

PDB 4HZH
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structure of prothrombin reveals conformational flexibility and mechanism of activation.
Pozzi, N., Chen, Z., Gohara, D.W., Niu, W., Heyduk, T., Di Cera, E.
J.Biol.Chem.