CATH Domain 4ggqA02

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.10	Roll
	3.10.50	Chitinase A; domain 3
	3.10.50.40

Domain Context

CATH Clusters

Superfamily	3.10.50.40
Functional Family	Fkbp-type peptidyl-prolyl cis-trans isomerase

Enzyme Information

5.2.1.8

Peptidylprolyl isomerase.

based on mapping to UniProt Q3JK38

Peptidylproline (omega=180) = peptidylproline (omega=0).

-!- The first type of this enzyme found proved to be the protein cyclophilin, which binds the immunosuppressant cyclosporin A. -!- Other distinct families of the enzyme exist, one being FK-506 binding proteins (FKBP) and another that includes parvulin from Escherichia coli. -!- The three families are structurally unrelated and can be distinguished by being inhibited by cyclosporin A, FK-506 and 5-hydroxy-1,4-naphthoquinone, respectively.

UniProtKB Entries (2)

Q3JK38	Q3JK38_BURP1 Burkholderia pseudomallei 1710b Peptidyl-prolyl cis-trans isomerase
Q12306	SMT3_YEAST Saccharomyces cerevisiae S288C Ubiquitin-like protein SMT3

PDB Structure

PDB	4GGQ
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	A structural biology approach enables the development of antimicrobials targeting bacterial immunophilins. Begley, D.W., Fox, D., Jenner, D., Juli, C., Pierce, P.G., Abendroth, J., Muruthi, M., Safford, K., Anderson, V., Atkins, K., Barnes, S.R., Moen, S.O., Raymond, A.C., Stacy, R., Myler, P.J., Staker, B.L., Harmer, N.J., Norville, I.H., Holzgrabe, U., Sarkar-Tyson, M., Edwards, T.E., Lorimer, D.D. Antimicrob.Agents Chemother.