CATH Classification
Level | CATH Code | Description |
---|---|---|
1 | Mainly Alpha | |
1.10 | Orthogonal Bundle | |
1.10.268 | Topoisomerase; domain 3 | |
1.10.268.10 | Topoisomerase, domain 3 |
Domain Context
CATH Clusters
Superfamily | Topoisomerase, domain 3 |
Functional Family | Probable DNA topoisomerase 2 |
Enzyme Information
5.99.1.3 |
DNA topoisomerase (ATP-hydrolyzing).
based on mapping to UniProt P11388
ATP-dependent breakage, passage and rejoining of double-stranded DNA.
-!- Can introduce negative superhelical turns into double-stranded circular DNA. -!- One unit has nicking-closing activity, and another catalyzes super- twisting and hydrolysis of ATP (cf. EC 5.99.1.2).
|
UniProtKB Entries (1)
P11388 |
TOP2A_HUMAN
Homo sapiens
DNA topoisomerase 2-alpha
|
PDB Structure
PDB | 4FM9 |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
The Structure of DNA-Bound Human Topoisomerase II Alpha: Conformational Mechanisms for Coordinating Inter-Subunit Interactions with DNA Cleavage.
J.Mol.Biol.
|