CATH Classification
Domain Context
CATH Clusters
Superfamily | 3.90.1200.10 |
Functional Family | Protein Bm8044, isoform b |
Enzyme Information
2.7.1.95 |
Kanamycin kinase.
based on mapping to UniProt B0VD92
ATP + kanamycin = ADP + kanamycin 3'-phosphate.
-!- Also acts on the antibiotics neomycin, paromomycin, neamine, paromamine, vistamycin and gentamicin A. -!- An enzyme from Pseudomonas aeruginosa also acts on butirosin.
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UniProtKB Entries (1)
B0VD92 |
B0VD92_ACIBY
Acinetobacter baumannii AYE
Aminoglycoside 3'-phosphotransferase AphA1-IAB
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PDB Structure
PDB | 4EJ7 |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Structure-guided optimization of protein kinase inhibitors reverses aminoglycoside antibiotic resistance.
Biochem.J.
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