CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.30 | 2-Layer Sandwich |
|
3.30.200 | Phosphorylase Kinase; domain 1 |
|
3.30.200.20 | Phosphorylase Kinase; domain 1 |
Domain Context
CATH Clusters
| Superfamily | Phosphorylase Kinase; domain 1 |
| Functional Family | Protein Bm8044, isoform b |
Enzyme Information
| 2.7.1.95 |
Kanamycin kinase.
based on mapping to UniProt B0VD92
ATP + kanamycin = ADP + kanamycin 3'-phosphate.
-!- Also acts on the antibiotics neomycin, paromomycin, neamine, paromamine, vistamycin and gentamicin A. -!- An enzyme from Pseudomonas aeruginosa also acts on butirosin.
|
UniProtKB Entries (1)
| B0VD92 |
B0VD92_ACIBY
Acinetobacter baumannii AYE
Aminoglycoside 3'-phosphotransferase AphA1-IAB
|
PDB Structure
| PDB | 4EJ7 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structure-guided optimization of protein kinase inhibitors reverses aminoglycoside antibiotic resistance.
Biochem.J.
|