CATH Classification

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family Thiamine biosynthesis protein ThiF

Enzyme Information
Sulfur carrier protein ThiS adenylyltransferase.
based on mapping to UniProt Q46927
ATP + [ThiS] = diphosphate + adenylyl-[ThiS].
-!- The enzyme catalyzes the adenylation of ThiS, a sulfur carrier protein involved in the biosynthesis of thiamine. -!- The enzyme shows significant structural similarity to ubiquitin- activating enzyme. -!- In Escherichia coli, but not in Bacillus subtilis, the enzyme forms a cross link from Cys-184 to the ThiS carboxy terminus (the position that is also thiolated) via an acyldisulfide. -!- Formerly EC 2.7.7.n3.
Forming carbon-oxygen bonds.
based on mapping to UniProt Q46927

UniProtKB Entries (1)

Escherichia coli K-12
TRNA threonylcarbamoyladenosine dehydratase

PDB Structure

PDB 4D79
External Links
Primary Citation
The Crystal Structure and Small-Angle X-Ray Analysis of Csdl/Tcda Reveal a New tRNA Binding Motif in the Moeb/E1 Superfamily.
Lopez-Estepa, M., Arda, A., Savko, M., Round, A., Shepard, W.E., Bruix, M., Coll, M., Fernandez, F.J., Jimenez-Barbero, J., Vega, M.C.
Plos One