CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.10 | Orthogonal Bundle |
|
1.10.460 | Topoisomerase I; domain 2 |
|
1.10.460.10 | Topoisomerase I, domain 2 |
Domain Context
CATH Clusters
| Superfamily | Topoisomerase I, domain 2 |
| Functional Family | DNA topoisomerase 3-alpha |
Enzyme Information
| 5.99.1.2 |
DNA topoisomerase.
based on mapping to UniProt Q13472
ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.
-!- Brings about the conversion of one topological isomer of DNA into another, e.g. the relaxation of superhelical turns in DNA, the interconversion of simple and knotted rings of single-stranded DNA, and the intertwisting of single-stranded rings of complementary sequences (cf. EC 5.99.1.3).
|
UniProtKB Entries (1)
| Q9H9A7 |
RMI1_HUMAN
Homo sapiens
RecQ-mediated genome instability protein 1
|
PDB Structure
| PDB | 4CGY |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structural and Mechanistic Insight Into Holliday-Junction Dissolution by Topoisomerase Iiialpha and Rmi1
Nat.Struct.Mol.Biol.
|