CATH Domain 4cgyA01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.140

Domain Context

CATH Clusters

Superfamily	3.40.50.140
Functional Family	DNA topoisomerase III (Eurofung)

Enzyme Information

5.99.1.2

DNA topoisomerase.

based on mapping to UniProt Q13472

ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.

-!- Brings about the conversion of one topological isomer of DNA into another, e.g. the relaxation of superhelical turns in DNA, the interconversion of simple and knotted rings of single-stranded DNA, and the intertwisting of single-stranded rings of complementary sequences (cf. EC 5.99.1.3).

UniProtKB Entries (1)

Q9H9A7

RMI1_HUMAN

Homo sapiens

RecQ-mediated genome instability protein 1

PDB Structure

PDB	4CGY
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structural and Mechanistic Insight Into Holliday-Junction Dissolution by Topoisomerase Iiialpha and Rmi1 Bocquet, N., Bizard, A.H., Abdulrahman, W., Larsen, N.B., Faty, M., Cavadini, S., Bunker, R.D., Kowalczykowski, S.C., Cejka, P., Hickson, I.D., Thoma, N.H. Nat.Struct.Mol.Biol.