CATH Classification

Domain Context

CATH Clusters

Superfamily Leucine Aminopeptidase, subunit E, domain 1
Functional Family Poly [ADP-ribose] polymerase 14

Enzyme Information

2.4.2.30
NAD(+) ADP-ribosyltransferase.
based on mapping to UniProt Q460N5
NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D- ribosyl)(n+1)-acceptor.
-!- The ADP-D-ribosyl group of NAD(+) is transferred to an acceptor carboxy group on a histone or the enzyme itself, and further ADP- ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units.

UniProtKB Entries (1)

Q460N5
PAR14_HUMAN
Homo sapiens
Poly [ADP-ribose] polymerase 14

PDB Structure

PDB 4ABK
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Recognition of Mono-Adp-Ribosylated Artd10 Substrates by Artd8 Macrodomains
Forst, A.H., Karlberg, T., Herzog, N., Thorsell, A.G., Gross, A., Feijs, K.L.H., Verheugd, P., Kursula, P., Nijmeijer, B., Kremmer, E., Kleine, H., Ladurner, A.G., Schuler, H., Luscher, B.
Structure