CATH Classification
Level | CATH Code | Description |
---|---|---|
3 | Alpha Beta | |
3.40 | 3-Layer(aba) Sandwich | |
3.40.220 | Leucine Aminopeptidase, subunit E; domain 1 | |
3.40.220.10 | Leucine Aminopeptidase, subunit E, domain 1 |
Domain Context
CATH Clusters
Superfamily | Leucine Aminopeptidase, subunit E, domain 1 |
Functional Family | Poly [ADP-ribose] polymerase 14 |
Enzyme Information
2.4.2.30 |
NAD(+) ADP-ribosyltransferase.
based on mapping to UniProt Q460N5
NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D- ribosyl)(n+1)-acceptor.
-!- The ADP-D-ribosyl group of NAD(+) is transferred to an acceptor carboxy group on a histone or the enzyme itself, and further ADP- ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units.
|
UniProtKB Entries (1)
Q460N5 |
PAR14_HUMAN
Homo sapiens
Poly [ADP-ribose] polymerase 14
|
PDB Structure
PDB | 4ABK |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Recognition of Mono-Adp-Ribosylated Artd10 Substrates by Artd8 Macrodomains
Structure
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