CATH Classification

Domain Context

CATH Clusters

Superfamily Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain
Functional Family O-methyltransferase family protein, expressed

Enzyme Information

2.1.1.4
Acetylserotonin O-methyltransferase.
based on mapping to UniProt P46597
S-adenosyl-L-methionine + N-acetylserotonin = S-adenosyl-L-homocysteine + melatonin.
-!- Some other hydroxyindoles also act as acceptor, more slowly.

UniProtKB Entries (1)

P46597
ASMT_HUMAN
Homo sapiens
Acetylserotonin O-methyltransferase

PDB Structure

PDB 4A6D
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal Structure and Functional Mapping of Human Asmt, the Last Enzyme of the Melatonin Synthesis Pathway.
Botros, H.G., Legrand, P., Pagan, C., Bondet, V., Weber, P., Ben-Abdallah, M., Lemiere, N., Huguet, G., Bellalou, J., Maronde, E., Beguin, P., Haouz, A., Shepard, W., Bourgeron, T.
J.Pineal Res.