CATH Domain 3wqkA01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.1180	Undecaprenyl pyrophosphate synthetase
	3.40.1180.10	Decaprenyl diphosphate synthase-like

Domain Context

CATH Clusters

Superfamily	Decaprenyl diphosphate synthase-like
Functional Family	Uncharacterized protein

Enzyme Information

3.1.7.9	Isotuberculosinol synthase. based on mapping to UniProt P9WJ61 Tuberculosinyl diphosphate + H(2)O = (13S)-isotuberculosinol + diphosphate. -!- Only found in species of Mycobacterium that cause tuberculosis. -!- In addition, it also gives tuberculosinol in 1:1 mixture, cf EC 3.1.7.8. -!- The isotuberculosinol form was a 3:1 mixture of the 13S and 13R forms, respectively.
3.1.7.8	Tuberculosinol synthase. based on mapping to UniProt P9WJ61 Tuberculosinyl diphosphate + H(2)O = tuberculosinol + diphosphate. -!- Only found in species of Mycobacterium that cause tuberculosis. -!- In addition, it also gives isotuberculosinol in 1:1 mixture, cf. EC 3.1.7.9.

UniProtKB Entries (1)

TUBOL_MYCTU

Mycobacterium tuberculosis H37Rv

Diterpene synthase

PDB Structure

PDB	3WQK
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structure and inhibition of tuberculosinol synthase and decaprenyl diphosphate synthase from Mycobacterium tuberculosis. Chan, H.C., Feng, X., Ko, T.P., Huang, C.H., Hu, Y., Zheng, Y., Bogue, S., Nakano, C., Hoshino, T., Zhang, L., Lv, P., Liu, W., Crick, D.C., Liang, P.H., Wang, A.H., Oldfield, E., Guo, R.T. J.Am.Chem.Soc.