CATH Classification
Domain Context
CATH Clusters
| Superfamily | Bovine Mitochondrial F1-atpase; Atp Synthase Beta Chain; Chain D, domain 3 |
| Functional Family | ATP synthase subunit A |
Enzyme Information
| 3.6.3.15 |
Sodium-transporting two-sector ATPase.
based on mapping to UniProt Q08636
ATP + H(2)O + Na(+)(In) = ADP + phosphate + Na(+)(Out).
-!- A multisubunit non-phosphorylated ATPase that is involved in the transport of ions. -!- An enzyme found in alkaliphilic bacteria that is similar to EC 3.6.3.14.
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| 3.6.3.14 |
H(+)-transporting two-sector ATPase.
based on mapping to UniProt Q08636
ATP + H(2)O + H(+)(In) = ADP + phosphate + H(+)(Out).
-!- A multisubunit non-phosphorylated ATPase that is involved in the transport of ions. -!- Large enzymes of mitochondria, chloroplasts and bacteria with a membrane sector (F(o), V(o), A(o)) and a cytoplasmic-compartment sector (F(1), V(1), A(1)). -!- The F-type enzymes of the inner mitochondrial and thylakoid membranes act as ATP synthases. -!- All of the enzymes included here operate in a rotational mode, where the extramembrane sector (containing 3 alpha- and 3 beta-subunits) is connected via the delta-subunit to the membrane sector by several smaller subunits. -!- Within this complex, the gamma- and epsilon-subunits, as well as the 9-12 c subunits rotate by consecutive 120 degree angles and perform parts of ATP synthesis. -!- This movement is driven by the H(+) electrochemical potential gradient. -!- The V-type (in vacuoles and clathrin-coated vesicles) and A-type (archaeal) enzymes have a similar structure but, under physiological conditions, they pump H(+) rather than synthesize ATP. -!- Formerly EC 3.6.1.34.
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UniProtKB Entries (1)
| Q08636 |
NTPA_ENTHA
Enterococcus hirae ATCC 9790
V-type sodium ATPase catalytic subunit A
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PDB Structure
| PDB | 3VR2 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Rotation mechanism of Enterococcus hirae V(1)-ATPase based on asymmetric crystal structures
Nature
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