CATH Classification

Domain Context

CATH Clusters

Superfamily Vaccinia Virus protein VP39
Functional Family Ribosomal RNA small subunit methyltransferase H

Enzyme Information

2.1.1.199
16S rRNA (cytosine(1402)-N(4))-methyltransferase.
based on mapping to UniProt P60390
S-adenosyl-L-methionine + cytosine(1402) in 16S rRNA = S-adenosyl-L- homocysteine + N(4)-methylcytosine(1402) in 16S rRNA.
-!- RsmH catalyzes the N(4)-methylation of cytosine(1402) and RsmI (EC 2.1.1.198) catalyzes the 2'-O-methylation of cytosine(1402) in 16S rRNA. -!- Both methylations are necessary for efficient translation initiation at the UUG and GUG codons.

UniProtKB Entries (1)

P60390
RSMH_ECOLI
Escherichia coli K-12
Ribosomal RNA small subunit methyltransferase H

PDB Structure

PDB 3TKA
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal and solution structures of methyltransferase RsmH provide basis for methylation of C1402 in 16S rRNA.
Wei, Y., Zhang, H., Gao, Z.Q., Wang, W.J., Shtykova, E.V., Xu, J.H., Liu, Q.S., Dong, Y.H.
J.Struct.Biol.