CATH Classification

Domain Context

CATH Clusters

Superfamily 3.40.630.30
Functional Family Polyketide synthase/nonribosomal peptide synthetase hybrid RzxA

Enzyme Information

2.3.1.87
Aralkylamine N-acetyltransferase.
based on mapping to UniProt Q94521
Acetyl-CoA + a 2-arylethylamine = CoA + an N-acetyl-2-arylethylamine.
-!- Narrow specificity toward 2-arylethylamines, including serotonin (5-hydroxytryptamine), tryptamine, 5-methoxytryptamine and phenylethylamine. -!- This is the penultimate enzyme in the production of melatonin (5-methoxy-N-acetyltryptamine) and controls its synthesis (cf. EC 2.1.1.4). -!- Differs from EC 2.3.1.5.

UniProtKB Entries (1)

Q94521
DNAT_DROME
Drosophila melanogaster
Dopamine N-acetyltransferase

PDB Structure

PDB 3TE4
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structure of the dopamine N-acetyltransferase-acetyl-CoA complex provides insights into the catalytic mechanism
Cheng, K.C., Liao, J.N., Lyu, P.C.
Biochem.J.