CATH Classification
Level | CATH Code | Description |
---|---|---|
1 | Mainly Alpha | |
1.25 | Alpha Horseshoe | |
1.25.40 | Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat | |
1.25.40.10 | Tetratricopeptide repeat domain |
Domain Context
CATH Clusters
Superfamily | 1.25.40.10 |
Functional Family | Tetratricopeptide repeat domain-containing protein |
Enzyme Information
2.3.2.27 |
RING-type E3 ubiquitin transferase.
based on mapping to UniProt Q9WUD1
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)- ubiquitinyl-[acceptor protein]-L-lysine.
-!- The RING domain of E3 ubiquitin transferase serves as a mediator bringing the ubiquitin-charged E2 ubiquitin-conjugating enzyme and the acceptor protein together to enable the direct transfer of ubiquitin through the formation of an isopeptide bond between the C-terminal glycine residue of ubiquitin an the epsilon-amino group of an L-lysine residue of the acceptor protein. -!- The RING-E3 domain does not form a catalytic thioester intermediate with ubiquitin (unlike the HECT domain, EC 2.3.2.26). -!- RING-type ubiquitin transferases may occur as single-chain enzymes but also in dimeric forms or in multi-subunit assemblies. -!- Formerly EC 6.3.2.19 and EC 6.3.2.21.
|
UniProtKB Entries (2)
Q9WUD1 |
CHIP_MOUSE
Mus musculus
STIP1 homology and U box-containing protein 1
|
P0DMV8 |
HS71A_HUMAN
Homo sapiens
Heat shock 70 kDa protein 1A
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PDB Structure
PDB | 3Q49 |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Molecular Mechanism of the Negative Regulation of Smad1/5 Protein by Carboxyl Terminus of Hsc70-interacting Protein (CHIP).
J.Biol.Chem.
|