CATH Classification

Domain Context

CATH Clusters

Superfamily SET domain
Functional Family Probable histone-lysine N-methyltransferase Mes-4

Enzyme Information

2.1.1.43
Histone-lysine N-methyltransferase.
based on mapping to UniProt Q96L73
S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].

UniProtKB Entries (1)

Q96L73
NSD1_HUMAN
Homo sapiens
Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific

PDB Structure

PDB 3OOI
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The structure of NSD1 reveals an autoregulatory mechanism underlying histone H3K36 methylation
Qiao, Q., Li, Y., Chen, Z., Wang, M., Reinberg, D., Xu, R.M.
J.Biol.Chem.