CATH Classification

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family Glutamyl-tRNA reductase 1

Enzyme Information
Glutamyl-tRNA reductase.
based on mapping to UniProt Q97B68
L-glutamate 1-semialdehyde + NADP(+) + tRNA(Glu) = L-glutamyl-tRNA(Glu) + NADPH.
-!- Forms part of the pathway for the biosynthesis of 5-aminolevulinate from glutamate, known as the C5 pathway, which is used in most eubacteria, and in all archaebacteria, algae and plants. -!- However, in the alpha-proteobacteria EC is used in an alternative route to produce the product 5-aminolevulinate from succinyl-CoA and glycine. -!- This route is found in the mitochondria of fungi and animals, organelles that are considered to be derived from an endosymbiotic alpha-proteobacterium. -!- Although higher plants do not possess EC, the protistan Euglena gracilis possesses both the C5 pathway and EC

UniProtKB Entries (1)

Thermoplasma volcanium GSS1
Glutamyl-tRNA reductase

PDB Structure

External Links
Primary Citation
Crystal structure of glutamyl-tRNA reductase from Thermoplasma volcanium (nucleotide binding domain)
Michalska, K., Marshall, N., Clancy, S., Puttagunta, R., Joachimiak, A., Midwest Center for Structural Genomics (MCSG)
To be Published