CATH Classification

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family Enoyl-[acyl-carrier-protein] reductase [NADPH] FabL

Enzyme Information

1.3.1.104
Enoyl-[acyl-carrier-protein] reductase.
based on mapping to UniProt P71079
An acyl-[acyl-carrier protein] + NADP(+) = a trans-2,3-dehydroacyl-[acyl- carrier protein] + NADPH.
-!- The enzyme completes each cycle of fatty acid elongation by catalyzing the stereospecific reduction of the double bond at position 2 of a growing fatty acid chain, while linked to the acyl- carrier protein, in an NADPH-dependent manner. -!- This entry stands for enzymes whose stereo-specificity with respect to NADP(+) is not known (cf. EC 1.3.1.39, EC 1.3.1.10 and EC 1.3.1.9).
1.3.1.10
Enoyl-[acyl-carrier-protein] reductase (NADPH, Si-specific).
based on mapping to UniProt P71079
An acyl-[acyl-carrier protein] + NADP(+) = a trans-2,3-dehydroacyl-[acyl- carrier protein] + NADPH.
-!- One of the activities of EC 2.3.1.86, an enzyme found in yeasts (Ascomycota and the Basidiomycota). -!- Catalyzes the reduction of enoyl-acyl-[acyl-carrier protein] derivatives of carbon chain length from 4 to 16. -!- The yeast enzyme is Si-specific with respect to NADP(+). -!- Cf. EC 1.3.1.39 and EC 1.3.1.104 which describes enzymes whose stereo-specificity toward NADPH is not known. -!- See also EC 1.3.1.9.

UniProtKB Entries (1)

P71079
FABL_BACSU
Bacillus subtilis subsp. subtilis str. 168
Enoyl-[acyl-carrier-protein] reductase [NADPH] FabL

PDB Structure

PDB 3OIC
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal Structures of Enoyl-ACP Reductases I (FabI) and III (FabL) from B. subtilis
Kim, K.-H., Ha, B.H., Kim, S.J., Hong, S.K., Hwang, K.Y., Kim, E.E.
J.Mol.Biol.