CATH Classification

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family Dehydrogenase/reductase SDR family member 4

Enzyme Information

1.1.1.184
Carbonyl reductase (NADPH).
based on mapping to UniProt Q9BTZ2
R-CHOH-R' + NADP(+) = R-CO-R' + NADPH.
-!- Acts on a wide range of carbonyl compounds, including quinones, aromatic aldehydes, ketoaldehydes, daunorubicin, and prostaglandins E and F, reducing them to the corresponding alcohol. -!- Si-specific with respect to NADPH (cf. EC 1.1.1.2).

UniProtKB Entries (1)

Q9BTZ2
DHRS4_HUMAN
Homo sapiens
Dehydrogenase/reductase SDR family member 4

PDB Structure

PDB 3O4R
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal Structure of Human Dehydrogenase/Reductase (SDR family) member 4 (DHRS4)
Ugochukwu, E., Bhatia, C., Krojer, T., Vollmar, M., Yue, W.W., Bountra, C., Arrowsmith, C.H., Weigelt, J., Edwards, A., von Delft, F., Oppermann, U.
To be Published