CATH Classification

Domain Context

CATH Clusters

Superfamily 3.40.50.1480
Functional Family Putative adenosylhomocysteinase 3

Enzyme Information

3.3.1.1
Adenosylhomocysteinase.
based on mapping to UniProt O43865
S-adenosyl-L-homocysteine + H(2)O = L-homocysteine + adenosine.
-!- The NAD(+) cofactor appears to bring about a transient oxidation at C-3' of the 5'-deoxyadenosine residue, thus labilizing the thioether bond cf. EC 5.5.1.4.

UniProtKB Entries (1)

O43865
SAHH2_HUMAN
Homo sapiens
Adenosylhomocysteinase 2

PDB Structure

PDB 3MTG
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structure of human S-adenosyl homocysteine hydrolase-like 1 protein
Wisniewska, M., Siponen, M.I., Arrowsmith, C.H., Berglund, H., Bountra, C., Collins, R., Edwards, A.M., Flodin, S., Flores, A., Graslund, S., Hammarstrom, M., Johansson, I., Karlberg, T., Kotenyova, T., Moche, M., Nordlund, P., Nyman, T., Persson, C., Schutz, P., Thorsell, A.G., Tresaugues, L., van der Berg, S., Wahlberg, E., Weigelt, J., Welin, M., Schuler, H.
TO BE PUBLISHED