CATH Classification

Domain Context

CATH Clusters

Superfamily Aromatic compound dioxygenase
Functional Family Protocatechuate 3,4-dioxygenase subunit beta

Enzyme Information

1.13.11.3
Protocatechuate 3,4-dioxygenase.
based on mapping to UniProt P00437
3,4-dihydroxybenzoate + O(2) = 3-carboxy-cis,cis-muconate.
-!- The enzyme, which participates in the degradation of aromatic compounds, catalyzes the intradiol addition of both oxygen atoms from molecular oxygen, resulting in ortho-cleavage of the aromatic ring. -!- The type of cleavage leads to mineralization via the intermediate 3-oxoadipate. -!- Formerly EC 1.13.1.3 and EC 1.99.2.3.

UniProtKB Entries (1)

P00436
PCXA_PSEPU
Pseudomonas putida
Protocatechuate 3,4-dioxygenase alpha chain

PDB Structure

PDB 3MFL
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Axial Ligand Swapping In Double Mutant Maintains Intradiol-cleavage Chemistry in Protocatechuate 3,4-Dioxygenase
Purpero, V.M., Lipscomb, J.D.
To be Published