CATH Classification

Domain Context

CATH Clusters

Superfamily Medium-chain alcohol dehydrogenases, catalytic domain
Functional Family Crotonyl-CoA reductase

Enzyme Information

1.3.1.86
Crotonyl-CoA reductase.
based on mapping to UniProt Q9ZBK1
Butanoyl-CoA + NADP(+) = (E)-but-2-enoyl-CoA + NADPH.
-!- Catalyzes the reaction in the reverse direction. -!- This enzyme from Streptomyces collinus is specific for (E)-but-2- enoyl-CoA, and is proposed to provide butanoyl-CoA as a starter unit for straight-chain fatty acid biosynthesis.

UniProtKB Entries (1)

Q9ZBK1
Q9ZBK1_STRCO
Streptomyces coelicolor A3(2)
Crotonyl CoA reductase

PDB Structure

PDB 3KRT
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
CRYSTAL STRUCTURE OF putative crotonyl CoA reductase from Streptomyces coelicolor A3(2)
Malashkevich, V.N., Patskovsky, Y., Toro, R., Sauder, J.M., Burley, S.K., Almo, S.C.
To be Published