CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.10 | Orthogonal Bundle |
|
1.10.630 | Cytochrome p450 |
|
1.10.630.10 | Cytochrome P450 |
Domain Context
CATH Clusters
| Superfamily | Cytochrome P450 |
| Functional Family | Cytochrome P450, family 51 |
Enzyme Information
| 1.14.13.70 |
Sterol 14-alpha-demethylase.
based on mapping to UniProt Q16850
A 14-alpha-methylsteroid + 3 O(2) + 3 NADPH = a Delta(14)-steroid + formate + 3 NADP(+) + 4 H(2)O.
-!- This heme-thiolate (P450) enzyme acts on a range of steroids with a 14-alpha-methyl group, such as obtusifoliol and lanosterol. -!- The enzyme catalyzes two successive hydroxylations of the 14-alpha- methyl group, followed by elimination as formate, leaving a 14(15) double bond.
|
UniProtKB Entries (1)
| Q16850 |
CP51A_HUMAN
Homo sapiens
Lanosterol 14-alpha demethylase
|
PDB Structure
| PDB | 3JUS |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structural basis of human CYP51 inhibition by antifungal azoles.
J. Mol. Biol.
|