CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.150 | Vaccinia Virus protein VP39 |
Domain Context
CATH Clusters
| Superfamily | Vaccinia Virus protein VP39 |
| Functional Family | Leucine carboxyl methyltransferase 1 |
Enzyme Information
| 2.1.1.233 |
[Phosphatase 2A protein]-leucine-carboxy methyltransferase.
based on mapping to UniProt Q9UIC8
S-adenosyl-L-methionine + [phosphatase 2A protein]-leucine = S-adenosyl- L-homocysteine + [phosphatase 2A protein]-leucine methyl ester.
-!- Methylates the C-terminal leucine of phosphatase 2A. -!- A key regulator of protein phosphatase 2A. -!- The methyl ester is hydrolyzed by EC 3.1.1.89. -!- Occurs mainly in the cytoplasm, Golgi region and late endosomes.
|
UniProtKB Entries (1)
| Q9UIC8 |
LCMT1_HUMAN
Homo sapiens
Leucine carboxyl methyltransferase 1
|
PDB Structure
| PDB | 3IEI |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structural Insights into Novel Functions of a pro-survival PP2A-specific Methyltransferase
To be Published
|