CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.30 | 2-Layer Sandwich |
|
3.30.420 | Nucleotidyltransferase; domain 5 |
|
3.30.420.10 | Ribonuclease H-like superfamily/Ribonuclease H |
Domain Context
CATH Clusters
| Superfamily | Ribonuclease H-like superfamily/Ribonuclease H |
| Functional Family | Pol polyprotein |
Enzyme Information
| 3.1.26.4 |
Ribonuclease H.
based on mapping to UniProt P0A7Y4
Endonucleolytic cleavage to 5'-phosphomonoester.
-!- Acts on RNA-DNA hybrids.
|
UniProtKB Entries (2)
| P0A7Y4 |
RNH_ECOLI
Escherichia coli K-12
Ribonuclease HI
|
| Q72547 |
Q72547_9HIV1
Human immunodeficiency virus 1
Reverse transcriptase/RNaseH
|
PDB Structure
| PDB | 3HYF |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
RNase H active site inhibitors of human immunodeficiency virus type 1 reverse transcriptase: design, biochemical activity, and structural information.
J.Med.Chem.
|