CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.720 | NAD(P)-binding Rossmann-like Domain |
Domain Context
CATH Clusters
| Superfamily | NAD(P)-binding Rossmann-like Domain |
| Functional Family | Udp-n-acetylmuramate:l-alanyl-gamma-d-glutamyl-meso-diaminopimelate ligase transmembrane protein |
Enzyme Information
| 6.3.2.45 |
UDP-N-acetylmuramate L-alanyl-gamma-D-glutamyl-meso-2,6- diaminoheptanedioate ligase.
based on mapping to UniProt Q4FVQ2
ATP + UDP-N-acetyl-alpha-D-muramate + L-alanyl-gamma-D-glutamyl-meso-2,6- diaminoheptanedioate = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl- gamma-D-glutamyl-meso-2,6-diaminoheptanedioate.
-!- The enzyme catalyzes the reincorporation into peptidoglycan of the tripeptide L-alanyl-gamma-D-glutamyl-2,6-meso-diaminoheptanedioate released during the maturation and constant remodeling of this bacterial cell wall polymer that occur during cell growth and division. -!- The enzyme can also use the tetrapeptide L-alanyl-gamma-D-glutamyl- meso-2,6-diaminoheptanedioyl-D-alanine or the pentapeptide L-alanyl- gamma-D-glutamyl-meso-2,6-diaminoheptanedioyl-D-alanyl-D-alanine in vivo and in vitro.
|
UniProtKB Entries (1)
| Q4FVQ2 |
Q4FVQ2_PSYA2
Psychrobacter arcticus 273-4
UDP-N-acetylmuramate--L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptandioate ligase
|
PDB Structure
| PDB | 3HN7 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structure and function of the first full-length murein Peptide ligase (mpl) cell wall recycling protein.
Plos One
|