CATH Classification

Domain Context

CATH Clusters

Superfamily DNA-directed RNA polymerase, subunit 2, domain 6
Functional Family DNA-directed RNA polymerase II subunit RPB2

Enzyme Information

2.7.7.6
DNA-directed RNA polymerase.
based on mapping to UniProt Q02061
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. -!- Can initiate a chain de novo. -!- In eukaryotes three forms of the enzyme have been distinguished on the basis of sensitivity of alpha-amanitin, and the type of RNA synthesized. -!- See also EC 2.7.7.19 and EC 2.7.7.48.

UniProtKB Entries (1)

Q02061
RPB2_SCHPO
Schizosaccharomyces pombe 972h-
DNA-directed RNA polymerase II subunit RPB2

PDB Structure

PDB 3H0G
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Schizosacharomyces pombe RNA polymerase II at 3.6-A resolution.
Spahr, H., Calero, G., Bushnell, D.A., Kornberg, R.D.
Proc.Natl.Acad.Sci.USA