CATH Classification

Domain Context

CATH Clusters

Superfamily Histidine kinase-like ATPase, C-terminal domain
Functional Family DNA gyrase subunit B

Enzyme Information

5.99.1.3
DNA topoisomerase (ATP-hydrolyzing).
based on mapping to UniProt P0A0K8
ATP-dependent breakage, passage and rejoining of double-stranded DNA.
-!- Can introduce negative superhelical turns into double-stranded circular DNA. -!- One unit has nicking-closing activity, and another catalyzes super- twisting and hydrolysis of ATP (cf. EC 5.99.1.2).

UniProtKB Entries (1)

P0A0K8
GYRB_STAAU
Staphylococcus aureus
DNA gyrase subunit B

PDB Structure

PDB 3G75
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Discovery of pyrazolthiazoles as novel and potent inhibitors of bacterial gyrase.
Ronkin, S.M., Badia, M., Bellon, S., Grillot, A.L., Gross, C.H., Grossman, T.H., Mani, N., Parsons, J.D., Stamos, D., Trudeau, M., Wei, Y., Charifson, P.S.
Bioorg.Med.Chem.Lett.