CATH Classification

Domain Context

CATH Clusters

Superfamily Ribonuclease Inhibitor
Functional Family E3 ubiquitin-protein ligase SspH2

Enzyme Information

6.3.2.-
Acid--amino-acid ligases (peptide synthases).
based on mapping to UniProt P0CE12
2.3.2.27
RING-type E3 ubiquitin transferase.
based on mapping to UniProt P0CE12
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)- ubiquitinyl-[acceptor protein]-L-lysine.
-!- The RING domain of E3 ubiquitin transferase serves as a mediator bringing the ubiquitin-charged E2 ubiquitin-conjugating enzyme and the acceptor protein together to enable the direct transfer of ubiquitin through the formation of an isopeptide bond between the C-terminal glycine residue of ubiquitin an the epsilon-amino group of an L-lysine residue of the acceptor protein. -!- The RING-E3 domain does not form a catalytic thioester intermediate with ubiquitin (unlike the HECT domain, EC 2.3.2.26). -!- RING-type ubiquitin transferases may occur as single-chain enzymes but also in dimeric forms or in multi-subunit assemblies. -!- Formerly EC 6.3.2.19 and EC 6.3.2.21.

UniProtKB Entries (1)

P0CE12
SSPH2_SALTY
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
E3 ubiquitin-protein ligase SspH2

PDB Structure

PDB 3G06
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
A family of Salmonella virulence factors functions as a distinct class of autoregulated E3 ubiquitin ligases.
Quezada, C.M., Hicks, S.W., Galan, J.E., Stebbins, C.E.
Proc.Natl.Acad.Sci.USA
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